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Target
Alpha-amylase
Ligand
BDBM50231670
Substrate
n/a
Meas. Tech.
ChEMBL_462051 (CHEMBL945826)
IC50
1150±n/a nM
Citation
 Zhou, Y; Zhao, Y; O' Boyle, KM; Murphy, PV Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. Bioorg Med Chem Lett 18:954-8 (2008) [PubMed]  Article 
Target
Name:
Alpha-amylase
Synonyms:
Alpha-glucosidase
Type:
PROTEIN
Mol. Mass.:
65231.69
Organism:
Bacillus stearothermophilus
Description:
ChEMBL_740884
Residue:
555
Sequence:
MKKTWWKEGVAYQIYPRSFMDANGDGIGDLRGIIEKLDYLVELGVDIVWICPIYRSPNADNGYDISDYYAIMDEFGTMDDFDELLAQAHRRGLKIILDLVINHTSDEHPWFIESRSSRDNPKRDWYIWRDGKDGREPNNWESIFGGSAWQYDERTGQYYLHLFDVKQPDLNWENSEVRQALYDMINWWLDKGIDGFRIDAISHIKKKPGLPDLPNPKGLKYVPSFAAHMNQPGIMEYLRELKEQTFARYDIMTVGEANGVTVDEAEQWVGEENGVFHMIFQFEHLGLWKRKADGSIDVRRLKRTLTKWQKGLENRGWNALFLENHDLPRSVSTWGNDREYWAESAKALGALYFFMQGTPFIYQGQEIGMTNVQFSDIRDYRDVAALRLYELERANGRTHEEVMKIIWKTGRDNSRTPMQWSDAPNAGFTTGTPWIKVNENYRTINVEAERRDPNSVWSFYRQMIQLRKANELFVYGAYDLLLENHPSIYAYTRTLGRDRALIIVNVSDRPSLYRYDGFRLQSSDLALSNYPVRPHKNATRFKLKPYEARVYIWKE
  
Inhibitor
Name:
BDBM50231670
Synonyms:
(2R,3R,4R,5S)-1-(8-(3-(3H-1,2,3-triazol-4-yl)phenoxy)octyl)-2-(hydroxymethyl)piperidine-3,4,5-triol | CHEMBL254339
Type:
Small organic molecule
Emp. Form.:
C22H34N4O5
Mol. Mass.:
434.5292
SMILES:
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCCCOc1cccc(c1)-c1c[nH]nn1 |r|
Structure:
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