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Target
Cyclin-dependent kinase 2
Ligand
BDBM50237851
Substrate
n/a
Meas. Tech.
ChEMBL_463093 (CHEMBL929003)
IC50
14±n/a nM
Citation
 Lee, J; Choi, H; Kim, KH; Jeong, S; Park, JW; Baek, CS; Lee, SH Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:2292-5 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50237851
Synonyms:
2-biphenyl-4-yl-N-[5-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-1H-indazol-3-yl]-acetamide | CHEMBL402759
Type:
Small organic molecule
Emp. Form.:
C24H22N4O3S
Mol. Mass.:
446.521
SMILES:
O=C(Cc1ccc(cc1)-c1ccccc1)Nc1n[nH]c2ccc(cc12)N1CCCS1(=O)=O
Structure:
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