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Target
Cyclin-dependent kinase 2
Ligand
BDBM50237865
Substrate
n/a
Meas. Tech.
ChEMBL_463093 (CHEMBL929003)
IC50
10±n/a nM
Citation
 Lee, J; Choi, H; Kim, KH; Jeong, S; Park, JW; Baek, CS; Lee, SH Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:2292-5 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50237865
Synonyms:
CHEMBL255262 | N-[5-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-1H-indazol-3-yl]-2-(3-fluoro-phenyl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C18H17FN4O3S
Mol. Mass.:
388.416
SMILES:
Fc1cccc(CC(=O)Nc2n[nH]c3ccc(cc23)N2CCCS2(=O)=O)c1
Structure:
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