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Target
Histamine H3 receptor
Ligand
BDBM50237877
Substrate
n/a
Meas. Tech.
ChEMBL_463102 (CHEMBL930008)
Ki
75±n/a nM
Citation
 Sasho, S; Seishi, T; Kawamura, M; Hirose, R; Toki, S; Shimada, JI Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. Bioorg Med Chem Lett 18:2288-91 (2008) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50237877
Synonyms:
2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)ethyl)-3-(naphthalen-1-ylmethyl)imidazolidin-2-ylidene)malononitrile | CHEMBL254985
Type:
Small organic molecule
Emp. Form.:
C26H34N6
Mol. Mass.:
430.5884
SMILES:
[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7](-[#6])-[#6])-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-c2cccc3ccccc23)\[#6]-1=[#6](/C#N)C#N
Structure:
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