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Target
Histamine H3 receptor
Ligand
BDBM50237877
Substrate
n/a
Meas. Tech.
ChEMBL_463101 (CHEMBL929011)
Ki
83±n/a nM
Citation
 Sasho, S; Seishi, T; Kawamura, M; Hirose, R; Toki, S; Shimada, JI Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. Bioorg Med Chem Lett 18:2288-91 (2008) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50237877
Synonyms:
2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)ethyl)-3-(naphthalen-1-ylmethyl)imidazolidin-2-ylidene)malononitrile | CHEMBL254985
Type:
Small organic molecule
Emp. Form.:
C26H34N6
Mol. Mass.:
430.5884
SMILES:
[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7](-[#6])-[#6])-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-c2cccc3ccccc23)\[#6]-1=[#6](/C#N)C#N
Structure:
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