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Target
DNA polymerase beta
Ligand
BDBM50242093
Substrate
n/a
Meas. Tech.
ChEMBL_550598 (CHEMBL999199)
IC50
32400±n/a nM
Citation
 Prakash Chaturvedula, VS; Hecht, SM; Gao, Z; Jones, SH; Feng, X; Kingston, DG New neolignans that inhibit DNA polymerase beta lyase. J Nat Prod 67:964-7 (2004) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50242093
Synonyms:
CHEMBL469849 | canellin C
Type:
Small organic molecule
Emp. Form.:
C20H24O6
Mol. Mass.:
360.401
SMILES:
CO[C@@]12[C@H](O)[C@@](CC=C)(CC(=O)[C@H]1O)[C@@H](C)[C@@H]2c1ccc2OCOc2c1 |r,THB:4:3:16.14:9.12.10|
Structure:
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