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Target
DNA polymerase beta
Ligand
BDBM50237597
Substrate
n/a
Meas. Tech.
ChEMBL_481350 (CHEMBL1001050)
IC50
22500±n/a nM
Citation
 Li, SS; Gao, Z; Feng, X; Hecht, SM Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta. J Nat Prod 67:1608-10 (2004) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM50237597
Synonyms:
7-hydroxy-3,7'-dicoumaryl ether | 7-hydroxy-3-(2-oxo-2H-chromen-7-yloxy)chromen-2-one | CHEMBL259025
Type:
Small organic molecule
Emp. Form.:
C18H10O6
Mol. Mass.:
322.2684
SMILES:
Oc1ccc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2c1
Structure:
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