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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50259823
Substrate
n/a
Meas. Tech.
ChEMBL_526200 (CHEMBL974769)
IC50
23600±n/a nM
Citation
 Puder, C; Wagner, K; Vettermann, R; Hauptmann, R; Potterat, O Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella sp. J Nat Prod 68:323-6 (2005) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50259823
Synonyms:
2,7,8-Trihydroxy-3-phenyl-1,4-dibenzofurandione | CHEMBL454473
Type:
Small organic molecule
Emp. Form.:
C18H10O6
Mol. Mass.:
322.2684
SMILES:
Oc1cc2oc3c(C(=O)C(=O)C(C3=O)c3ccccc3)c2cc1O
Structure:
Search PDB for entries with ligand similarity: