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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50259897
Substrate
n/a
Meas. Tech.
ChEMBL_526200 (CHEMBL974769)
IC50
14500±n/a nM
Citation
 Puder, C; Wagner, K; Vettermann, R; Hauptmann, R; Potterat, O Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella sp. J Nat Prod 68:323-6 (2005) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50259897
Synonyms:
2,5-Dihydroxy-3-(3,4-dihydroxyphenyl)-6-phenyl-1,4-benzoquinone | CHEMBL541995
Type:
Small organic molecule
Emp. Form.:
C18H12O6
Mol. Mass.:
324.2843
SMILES:
Oc1ccc(cc1O)C1C(=O)C(=O)C(C(=O)C1=O)c1ccccc1 |(4.74,-13.67,;3.2,-13.75,;2.36,-12.45,;.83,-12.52,;.13,-13.89,;.96,-15.19,;2.49,-15.11,;3.32,-16.41,;-1.41,-13.96,;-2.24,-12.67,;-1.54,-11.3,;-3.79,-12.74,;-4.62,-11.44,;-4.48,-14.11,;-3.65,-15.4,;-4.35,-16.77,;-2.12,-15.33,;-1.28,-16.62,;-6.02,-14.18,;-6.86,-12.89,;-8.39,-12.97,;-9.1,-14.34,;-8.27,-15.63,;-6.73,-15.57,)|
Structure:
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