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Target
Forkhead box protein O1
Ligand
BDBM50259870
Substrate
n/a
Meas. Tech.
ChEMBL_525852 (CHEMBL972962)
IC50
5000±n/a nM
Citation
 Schroeder, FC; Kau, TR; Silver, PA; Clardy, J The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod 68:574-6 (2005) [PubMed]  Article 
Target
Name:
Forkhead box protein O1
Synonyms:
FKHR | FOXO1 | FOXO1A | FOXO1_HUMAN
Type:
PROTEIN
Mol. Mass.:
69663.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_525852
Residue:
655
Sequence:
MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG
  
Inhibitor
Name:
BDBM50259870
Synonyms:
CHEMBL481437 | psammaplysene A
Type:
Small organic molecule
Emp. Form.:
C27H35Br4N3O3
Mol. Mass.:
769.201
SMILES:
CN(C)CCCOc1c(Br)cc(\C=C\C(=O)NCCCOc2c(Br)cc(CCN(C)C)cc2Br)cc1Br
Structure:
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