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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50005639
Substrate
n/a
Meas. Tech.
ChEMBL_551745 (CHEMBL1000881)
IC50
3800±n/a nM
Citation
 Bohr, G; Gerhäuser, C; Knauft, J; Zapp, J; Becker, H Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus). J Nat Prod 68:1545-8 (2005) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM50005639
Synonyms:
2-(2-Methylpropanoyl)-1,3,5-benzenetriol | 2-Methyl-1-(2,4,6-trihydroxy-phenyl)-propan-1-one | CHEMBL20038
Type:
Small organic molecule
Emp. Form.:
C10H12O4
Mol. Mass.:
196.1999
SMILES:
CC(C)C(=O)c1c(O)cc(O)cc1O
Structure:
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