Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM50260259
Substrate
n/a
Meas. Tech.
ChEMBL_508499 (CHEMBL1003193)
EC50
11000±n/a nM
Citation
 Bright, DP; Adham, SD; Lemaire, LC; Benavides, R; Gruss, M; Taylor, GW; Smith, EH; Franks, NP Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel. J Biol Chem 282:12038-47 (2007) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
Benzodiazepine central | GABA A Benzodiazepine brain | GABA A Benzodiazepine liver | GABA receptor alpha-1 subunit | GABA(A) receptor subunit alpha-1 | GABA-A | GABA-A receptor | GABRA1 | GBRA1_HUMAN | Gamma-aminobutyric acid receptor subunit alpha (GABAA) | TBPS | agonist GABA site
Type:
Protein
Mol. Mass.:
51817.35
Organism:
Homo sapiens (Human)
Description:
P14867
Residue:
456
Sequence:
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
  
Inhibitor
Name:
BDBM50260259
Synonyms:
CHEMBL483019 | R(+)-azido(1-(1-phenylethyl)-1H-imidazol-5-yl)methanone
Type:
Small organic molecule
Emp. Form.:
C12H11N5O
Mol. Mass.:
241.2486
SMILES:
C[C@H](c1ccccc1)n1cncc1C(=O)N=[N+]=[N-] |r|
Structure:
Search PDB for entries with ligand similarity: