Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 1
Ligand
BDBM50269948
Substrate
n/a
Meas. Tech.
ChEMBL_505237 (CHEMBL941344)
IC50
486±n/a nM
Citation
Slack-Davis, JK; Martin, KH; Tilghman, RW; Iwanicki, M; Ung, EJ; Autry, C; Luzzio, MJ; Cooper, B; Kath, JC; Roberts, WG; Parsons, JT Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem 282:14845-52 (2007) [PubMed] Article
More Info.:
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Inhibitor
Name:
BDBM50269948
Synonyms:
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one | CHEMBL514554 | D3RKN_2 | PF-228 | US10266549, Example 32 | US10774092, Example 32
Type:
Small organic molecule
Emp. Form.:
C22H20F3N5O3S
Mol. Mass.:
491.486
SMILES:
CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1