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Target
cGMP-dependent 3',5'-cyclic phosphodiesterase
Ligand
BDBM50242771
Substrate
n/a
Meas. Tech.
ChEMBL_532145 (CHEMBL970332)
IC50
56000±n/a nM
Citation
 Raboisson, P; Schultz, D; Muller, C; Reimund, JM; Pinna, G; Mathieu, R; Bernard, P; Do, QT; Desjarlais, RL; Justiano, H; Lugnier, C; Bourguignon, JJ Cyclic nucleotide phosphodiesterase type 4 inhibitors: evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere. Eur J Med Chem 43:816-29 (2008) [PubMed]  Article 
Target
Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase
Synonyms:
PDE2A | PDE2A_BOVIN | Phosphodiesterase 2A
Type:
PROTEIN
Mol. Mass.:
103200.18
Organism:
Bos taurus
Description:
ChEMBL_154420
Residue:
921
Sequence:
MRRQPAASRDLFAQEPVPPGSGDGALQDALLSLGSVIDVAGLQQAVKEALSAVLPKVETVYTYLLDGESRLVCEEPPHELPQEGKVREAVISRKRLGCNGLGPSDLPGKPLARLVAPLAPDTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALKRVQALQQRESSVAPEATQNPPEEAAGDQKGGVAYTNQDRKILQLCGELYDLDASSLQLKVLQYLQQETQASRCCLLLVSEDNLQLSCKVIGDKVLEEEISFPLTTGRLGQVVEDKKSIQLKDLTSEDMQQLQSMLGCEVQAMLCVPVISRATDQVVALACAFNKLGGDLFTDQDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVEDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDMEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRTNKQHHSLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGARAPINGCCSLDAE
  
Inhibitor
Name:
BDBM50242771
Synonyms:
8-Benzyl-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine | CHEMBL508705
Type:
Small organic molecule
Emp. Form.:
C14H15N5
Mol. Mass.:
253.3024
SMILES:
CNc1nc(C)nc2c(Cc3ccccc3)cnn12
Structure:
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