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Target
Cyclin-dependent kinase 5
Ligand
BDBM50186073
Substrate
n/a
Meas. Tech.
ChEMBL_519478 (CHEMBL951784)
IC50
4000±n/a nM
Citation
 Logé, C; Testard, A; Thiéry, V; Lozach, O; Blairvacq, M; Robert, JM; Meijer, L; Besson, T Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies. Eur J Med Chem 43:1469-77 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50186073
Synonyms:
CHEMBL210229 | N-(2-(dimethylamino)ethyl)-8-isopropyl-9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carboxamidine | N-(2-Dimethylamino-ethyl)-8-isopopyl-9-oxo-8,9-dihydro[1,3]thiazolo[5,4-f]quinazoline-2-carboxamidine
Type:
Small organic molecule
Emp. Form.:
C17H22N6OS
Mol. Mass.:
358.461
SMILES:
CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C
Structure:
Search PDB for entries with ligand similarity: