Reaction Details Report a problem with these data
Target
Baculoviral IAP repeat-containing protein 2
Ligand
BDBM50251284
Substrate
n/a
Meas. Tech.
ChEMBL_533438 (CHEMBL984306)
IC50
45200±n/a nM
Citation
 Sato, S; Tetsuhashi, M; Sekine, K; Miyachi, H; Naito, M; Hashimoto, Y; Aoyama, H Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. Bioorg Med Chem 16:4685-98 (2008) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 2
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48
Type:
Protein
Mol. Mass.:
69900.47
Organism:
Homo sapiens (Human)
Description:
Q13490
Residue:
618
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
  
Inhibitor
Name:
BDBM50251284
Synonyms:
CHEMBL458564 | N-[(R)-3-Hydroxycarbamoyl-2-benzylpropanyl]-L-leucine methyl ester
Type:
Small organic molecule
Emp. Form.:
C18H26N2O5
Mol. Mass.:
350.4094
SMILES:
COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: