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Target
Cytochrome c oxidase subunit 1
Ligand
BDBM50229774
Substrate
n/a
Meas. Tech.
ChEMBL_530100 (CHEMBL967598)
IC50
157200±n/a nM
Citation
 Erdélyi, P; Fodor, T; Varga, AK; Czugler, M; Gere, A; Fischer, J Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib. Bioorg Med Chem 16:5322-30 (2008) [PubMed]  Article 
Target
Name:
Cytochrome c oxidase subunit 1
Synonyms:
COI | COX1_SHEEP | COXI | MT-CO1 | MTCO1
Type:
PROTEIN
Mol. Mass.:
57042.19
Organism:
Ovis aries
Description:
ChEMBL_662814
Residue:
514
Sequence:
MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMIFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK
  
Inhibitor
Name:
BDBM50229774
Synonyms:
CHEMBL254418 | N-Hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide monohydrate | N-hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide hydrate
Type:
Small organic molecule
Emp. Form.:
C16H14N2O4S
Mol. Mass.:
330.358
SMILES:
Cc1onc(c1-c1ccc(cc1)S(=O)(=O)NO)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: