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Target
D-aspartate oxidase
Ligand
BDBM23174
Substrate
n/a
Meas. Tech.
ChEMBL_556667 (CHEMBL958954)
IC50
>5000±n/a nM
Citation
 Sparey, T; Abeywickrema, P; Almond, S; Brandon, N; Byrne, N; Campbell, A; Hutson, PH; Jacobson, M; Jones, B; Munshi, S; Pascarella, D; Pike, A; Prasad, GS; Sachs, N; Sakatis, M; Sardana, V; Venkatraman, S; Young, MB The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett 18:3386-91 (2008) [PubMed]  Article 
Target
Name:
D-aspartate oxidase
Synonyms:
D-Aspartate Oxidase (DDO) | DASOX | DDO | OXDD_HUMAN
Type:
Oxidoreductase
Mol. Mass.:
37543.06
Organism:
Homo sapiens (Human)
Description:
Recombinant human DDO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:
341
Sequence:
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
  
Inhibitor
Name:
BDBM23174
Synonyms:
6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]isoxazol-3-ol | CBIO | CHEMBL445990
Type:
Small organic molecule
Emp. Form.:
C7H4ClNO2
Mol. Mass.:
169.565
SMILES:
Clc1ccc2c(c1)o[nH]c2=O
Structure:
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