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Target
Queuine tRNA-ribosyltransferase catalytic subunit 1
Ligand
BDBM50271082
Substrate
n/a
Meas. Tech.
ChEMBL_553551 (CHEMBL958734)
Ki
3700±n/a nM
Citation
 Congreve, M; Chessari, G; Tisi, D; Woodhead, AJ Recent developments in fragment-based drug discovery. J Med Chem 51:3661-80 (2008) [PubMed]  Article 
Target
Name:
Queuine tRNA-ribosyltransferase catalytic subunit 1
Synonyms:
QTRT1 | Queuine tRNA-ribosyltransferase | TGT | TGT_HUMAN | TGUT
Type:
PROTEIN
Mol. Mass.:
44051.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_553551
Residue:
403
Sequence:
MAGAATQASLESAPRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLDALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQNLFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAVRTSIVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG
  
Inhibitor
Name:
BDBM50271082
Synonyms:
4-(4-methoxyphenethyl)-6-amino-3H-imidazo[4,5-g]quinazolin-8(7H)-one | 6-AMINO-4-[2-(4-METHOXYPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE | CHEMBL487739
Type:
Small organic molecule
Emp. Form.:
C18H17N5O2
Mol. Mass.:
335.3599
SMILES:
COc1ccc(CCc2c3[nH]cnc3cc3c2nc(N)[nH]c3=O)cc1
Structure:
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