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Target
Thymidylate kinase
Ligand
BDBM50271448
Substrate
n/a
Meas. Tech.
ChEMBL_556415 (CHEMBL954907)
Ki
6500±n/a nM
Citation
 Gasse, C; Douguet, D; Huteau, V; Marchal, G; Munier-Lehmann, H; Pochet, S Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity. Bioorg Med Chem 16:6075-85 (2008) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50271448
Synonyms:
5-[5-Chloro-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl-methyl)-phenyl]-butanoic acid | CHEMBL520293
Type:
Small organic molecule
Emp. Form.:
C15H15ClN2O4
Mol. Mass.:
322.744
SMILES:
OC(=O)CCCc1ccc(Cn2cc(Cl)c(=O)[nH]c2=O)cc1
Structure:
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