Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50271662
Substrate
n/a
Meas. Tech.
ChEMBL_556513 (CHEMBL956508)
IC50
56200±n/a nM
Citation
 Sundriyal, S; Viswanad, B; Bharathy, E; Ramarao, P; Chakraborti, AK; Bharatam, PV New PPARgamma ligands based on 2-hydroxy-1,4-naphthoquinone: computer-aided design, synthesis, and receptor-binding studies. Bioorg Med Chem Lett 18:3192-5 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
Nr1c3 | PPARG_RAT | Pparg
Type:
PROTEIN
Mol. Mass.:
57562.54
Organism:
Rattus norvegicus
Description:
ChEMBL_642067
Residue:
505
Sequence:
MGETLGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50271662
Synonyms:
2-(4-(2-(4-methoxyphenoxy)ethoxy)benzyl)-3-hydroxynaphthalene-1,4-dione | CHEMBL482531
Type:
Small organic molecule
Emp. Form.:
C26H22O6
Mol. Mass.:
430.4493
SMILES:
COc1ccc(OCCOc2ccc(CC3C(=O)C(=O)c4ccccc4C3=O)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: