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Target
Macrophage metalloelastase
Ligand
BDBM50240863
Substrate
n/a
Meas. Tech.
ChEMBL_556874 (CHEMBL964734)
IC50
290±n/a nM
Citation
 Nordström, H; Gossas, T; Hämäläinen, M; Källblad, P; Nyström, S; Wallberg, H; Danielson, UH Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library. J Med Chem 51:3449-59 (2008) [PubMed]  Article 
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM50240863
Synonyms:
5-Phenyl-imidazolidine-2,4-dione | 5-phenylimidazolidine-2,4-dione | CHEMBL156406
Type:
Small organic molecule
Emp. Form.:
C9H8N2O2
Mol. Mass.:
176.172
SMILES:
Oc1[nH]c(=O)[nH]c1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: