Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50267353
Substrate
n/a
Meas. Tech.
ChEMBL_563916 (CHEMBL965019)
Ki
320±n/a nM
Citation
 Bedürftig, S; Wünsch, B 1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity. Eur J Med Chem 44:519-25 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50267353
Synonyms:
(-)-[(2R)-1-Benzyl-4-(2,2-dimethoxyethyl)-1,4-diazepan-2-yl]methanol | CHEMBL518434
Type:
Small organic molecule
Emp. Form.:
C17H28N2O3
Mol. Mass.:
308.4158
SMILES:
COC(CN1CCCN(Cc2ccccc2)[C@@H](CO)C1)OC |r|
Structure:
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