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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270885
Substrate
n/a
Meas. Tech.
ChEMBL_552585 (CHEMBL956457)
pH
6±n/a
Kd
490±n/a nM
Comments
extracted
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270885
Synonyms:
CHEMBL508377
Type:
Small organic molecule
Emp. Form.:
C85H122N24O22S2
Mol. Mass.:
1896.156
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)C(C)(C)S)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O |r,wU:72.75,50.60,42.44,83.87,28.36,4.4,89.91,104.109,114.118,129.135,wD:61.71,46.48,17.25,108.112,12.12,(36.62,3.33,;36.62,1.79,;37.95,1.02,;35.29,1.02,;35.29,-.52,;33.95,-1.29,;32.61,-.52,;32.61,1.02,;31.29,-1.29,;29.95,-.52,;28.61,-1.29,;28.61,-2.83,;27.28,-.53,;27.28,1.01,;25.95,-1.29,;24.61,-.52,;24.61,1.02,;23.28,-1.29,;23.28,-2.83,;24.61,-3.6,;25.93,-2.84,;27.27,-3.6,;27.27,-5.14,;25.95,-5.91,;24.61,-5.15,;21.95,-.52,;20.61,-1.29,;20.61,-2.83,;19.28,-.52,;19.28,1.02,;20.61,1.79,;22.03,1.16,;23.05,2.31,;22.27,3.63,;20.77,3.31,;17.95,-1.29,;16.61,-.52,;16.61,1.02,;15.28,-1.29,;13.95,-.52,;12.61,-1.29,;12.61,-2.83,;11.28,-.52,;9.94,-1.29,;8.61,-.52,;8.61,1.02,;7.28,-1.29,;5.94,-.52,;4.61,-1.29,;4.61,-2.83,;3.28,-.52,;3.28,1.02,;4.61,1.79,;5.96,1.02,;7.27,1.79,;7.27,3.32,;5.94,4.09,;4.61,3.31,;1.94,-1.29,;.61,-.52,;.61,1.02,;-.72,-1.29,;-.72,-2.83,;.61,-3.6,;.61,-5.14,;1.94,-5.91,;1.94,-7.45,;.61,-8.22,;3.28,-8.22,;-2.06,-.52,;-3.4,-1.29,;-3.4,-2.83,;-4.72,-.52,;-6.06,-1.29,;-4.72,1.02,;-3.4,1.79,;-3.4,3.33,;-4.72,4.1,;-2.06,4.1,;7.28,-2.83,;8.82,-2.83,;5.74,-2.83,;7.28,-4.37,;11.28,1.02,;9.94,1.79,;12.61,1.79,;36.62,-1.29,;36.62,-2.83,;37.95,-.52,;39.29,-1.29,;40.62,-.52,;40.62,1.02,;39.3,1.78,;39.29,3.32,;40.62,4.09,;40.62,5.63,;41.95,3.33,;41.96,1.79,;39.29,-2.83,;37.95,-3.6,;40.62,-3.6,;42.18,-3.07,;43.21,-4.41,;42.26,-5.78,;40.87,-5.11,;39.63,-6.03,;38.22,-5.43,;39.82,-7.56,;38.59,-8.48,;37.18,-7.88,;35.94,-8.81,;38.77,-10.01,;40.19,-10.62,;37.55,-10.94,;37.73,-12.47,;39.15,-13.07,;39.34,-14.6,;38.1,-15.53,;40.75,-15.2,;36.5,-13.39,;35.08,-12.79,;36.69,-14.92,;35.46,-15.85,;35.64,-17.37,;37.05,-17.98,;34.41,-18.3,;34.3,-19.98,;32.69,-20.41,;31.78,-19,;32.94,-17.98,;32.56,-16.48,;31.07,-16.08,;33.65,-15.39,)|
Structure:
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