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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270797
Substrate
n/a
Meas. Tech.
ChEMBL_552585 (CHEMBL956457)
pH
6±n/a
Kd
10000±n/a nM
Comments
extracted
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270797
Synonyms:
CHEMBL505689 | RFCTGHFGGLYPC
Type:
Small organic molecule
Emp. Form.:
C66H92N18O16S2
Mol. Mass.:
1457.678
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCN=C(N)N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(O)=O |r,wU:16.24,45.49,62.65,96.100,wD:92.97,27.35,51.61,41.43,4.4,77.79,71.75,(27.74,-54.27,;27.74,-52.73,;29.07,-51.96,;26.4,-51.96,;26.4,-50.42,;25.07,-49.66,;23.74,-50.42,;23.74,-51.96,;22.4,-49.65,;21.07,-50.43,;19.74,-49.66,;19.74,-48.12,;18.41,-50.43,;17.07,-49.66,;15.74,-50.42,;15.74,-51.96,;14.4,-49.65,;14.4,-48.11,;15.74,-47.34,;17.06,-48.1,;18.39,-47.34,;18.4,-45.8,;17.08,-45.02,;15.74,-45.79,;13.07,-50.43,;11.74,-49.66,;11.74,-48.12,;10.4,-50.43,;10.4,-51.97,;11.74,-52.74,;13.15,-52.11,;14.17,-53.26,;13.4,-54.59,;11.89,-54.27,;9.06,-49.67,;7.72,-50.43,;7.72,-51.97,;6.39,-49.66,;5.06,-50.43,;3.72,-49.66,;3.72,-48.12,;2.39,-50.43,;1.06,-49.66,;-.28,-50.43,;-.28,-51.97,;-1.61,-49.66,;-1.61,-48.12,;-.28,-47.35,;-2.94,-50.43,;-4.27,-49.65,;-4.27,-48.11,;-5.61,-50.42,;-5.61,-51.96,;-4.27,-52.73,;-2.94,-51.95,;-1.6,-52.73,;-1.62,-54.27,;-2.95,-55.03,;-4.27,-54.26,;-6.95,-49.66,;-8.3,-50.41,;-8.3,-51.95,;-9.63,-49.64,;-10.95,-50.41,;-9.63,-48.1,;-8.3,-47.33,;-8.3,-45.79,;-6.95,-45.03,;-6.97,-43.49,;-8.29,-42.75,;-5.63,-42.73,;2.39,-51.97,;1.06,-52.74,;3.72,-52.74,;27.74,-49.65,;27.74,-48.11,;29.07,-50.43,;30.4,-49.65,;31.74,-50.42,;31.74,-51.96,;30.42,-52.72,;30.41,-54.26,;31.74,-55.04,;31.74,-56.59,;33.08,-54.28,;33.09,-52.74,;30.4,-48.11,;29.07,-47.34,;31.74,-47.34,;33.31,-47.87,;34.34,-46.54,;33.39,-45.15,;31.99,-45.84,;30.76,-44.91,;29.35,-45.52,;30.95,-43.38,;29.72,-42.46,;28.3,-43.06,;27.07,-42.14,;29.9,-40.93,;28.67,-40,;31.32,-40.32,)|
Structure:
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