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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270796
Substrate
n/a
Meas. Tech.
ChEMBL_552585 (CHEMBL956457)
pH
6±n/a
Kd
6100±n/a nM
Comments
extracted
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270796
Synonyms:
CHEMBL524509 | QRFCTGHFGGLYPCN
Type:
Small organic molecule
Emp. Form.:
C75H107N23O19S2
Mol. Mass.:
1698.925
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O |r,wU:101.106,73.76,27.35,51.61,4.4,86.88,41.43,80.84,111.115,wD:62.72,16.24,45.49,105.109,(32.43,-20.26,;32.43,-21.8,;33.77,-22.57,;31.1,-22.57,;31.1,-24.11,;29.77,-24.88,;28.43,-24.11,;28.43,-22.57,;27.1,-24.88,;25.77,-24.11,;24.43,-24.88,;24.43,-26.42,;23.1,-24.11,;21.77,-24.88,;20.43,-24.11,;20.43,-22.57,;19.1,-24.88,;19.1,-26.42,;20.43,-27.19,;21.75,-26.42,;23.08,-27.19,;23.1,-28.73,;21.77,-29.5,;20.43,-28.75,;17.77,-24.11,;16.43,-24.88,;16.43,-26.42,;15.1,-24.11,;15.1,-22.57,;16.43,-21.8,;17.85,-22.43,;18.87,-21.29,;18.09,-19.95,;16.59,-20.27,;13.76,-24.86,;12.41,-24.11,;12.41,-22.57,;11.08,-24.88,;9.75,-24.11,;8.41,-24.88,;8.41,-26.42,;7.08,-24.11,;5.75,-24.88,;4.41,-24.11,;4.41,-22.57,;3.08,-24.88,;3.08,-26.42,;4.41,-27.19,;1.75,-24.11,;.41,-24.87,;.41,-26.41,;-.92,-24.1,;-.92,-22.56,;.41,-21.79,;1.76,-22.56,;3.09,-21.79,;3.08,-20.25,;1.75,-19.48,;.41,-20.27,;-2.26,-24.87,;-3.59,-24.1,;-3.59,-22.56,;-4.92,-24.87,;-4.92,-26.41,;-3.59,-27.18,;-3.59,-28.72,;-2.26,-29.49,;-2.25,-31.03,;-3.59,-31.8,;-.92,-31.8,;-6.25,-24.09,;-7.57,-24.87,;-7.57,-26.41,;-8.91,-24.1,;-10.24,-24.86,;-8.91,-22.56,;-7.57,-21.79,;-7.57,-20.25,;-8.91,-19.48,;-6.24,-19.48,;7.08,-22.57,;5.75,-21.8,;8.41,-21.8,;32.43,-24.88,;32.43,-26.42,;33.77,-24.11,;35.1,-24.88,;36.44,-24.11,;36.44,-22.57,;35.12,-21.8,;35.11,-20.26,;36.43,-19.49,;36.43,-17.95,;37.77,-20.26,;37.79,-21.8,;35.1,-26.42,;33.77,-27.19,;36.44,-27.19,;38.01,-26.67,;39.03,-27.99,;38.08,-29.38,;36.68,-28.71,;35.37,-29.51,;34.02,-28.77,;35.42,-31.05,;34.11,-31.85,;32.75,-31.12,;31.44,-31.93,;34.15,-33.39,;35.51,-34.13,;32.84,-34.2,;32.89,-35.74,;34.24,-36.47,;34.28,-38.01,;32.97,-38.82,;35.63,-38.75,;31.57,-36.55,;31.61,-38.09,;30.22,-35.82,)|
Structure:
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