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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270795
Substrate
n/a
Meas. Tech.
ChEMBL_552585 (CHEMBL956457)
pH
6±n/a
Kd
4600±n/a nM
Comments
extracted
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270795
Synonyms:
CHEMBL503730 | QRFCTGHFGGLYPCNG
Type:
Small organic molecule
Emp. Form.:
C77H109N23O21S2
Mol. Mass.:
1756.961
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(O)=O |r,wU:101.106,27.35,51.61,4.4,86.88,41.43,80.84,111.115,73.76,wD:62.72,16.24,45.49,105.109,(30.03,4.17,;30.03,2.63,;31.36,1.86,;28.7,1.86,;28.7,.32,;27.36,-.45,;26.03,.32,;26.03,1.86,;24.69,-.45,;23.36,.32,;22.03,-.45,;22.03,-1.99,;20.7,.32,;19.36,-.45,;18.03,.32,;18.03,1.86,;16.69,-.45,;16.69,-1.99,;18.03,-2.76,;19.35,-1.99,;20.68,-2.76,;20.69,-4.3,;19.37,-5.07,;18.03,-4.32,;15.36,.32,;14.03,-.45,;14.03,-1.99,;12.7,.32,;12.7,1.86,;14.03,2.63,;15.44,1.99,;16.47,3.14,;15.69,4.48,;14.18,4.16,;11.35,-.43,;10.01,.32,;10.01,1.86,;8.68,-.45,;7.34,.32,;6.01,-.45,;6.01,-1.99,;4.68,.32,;3.34,-.45,;2.01,.32,;2.01,1.86,;.67,-.45,;.67,-1.99,;2.01,-2.76,;-.66,.32,;-1.99,-.44,;-1.99,-1.98,;-3.33,.33,;-3.33,1.87,;-1.99,2.64,;-.64,1.86,;.69,2.64,;.68,4.18,;-.66,4.94,;-1.99,4.16,;-4.66,-.44,;-5.99,.33,;-5.99,1.87,;-7.32,-.44,;-7.32,-1.98,;-5.99,-2.75,;-5.99,-4.29,;-4.66,-5.06,;-4.66,-6.6,;-5.99,-7.37,;-3.32,-7.37,;-8.65,.34,;-9.98,-.44,;-9.98,-1.98,;-11.31,.33,;-12.65,-.44,;-11.31,1.87,;-9.98,2.64,;-9.98,4.18,;-11.31,4.95,;-8.64,4.95,;4.68,1.86,;3.34,2.63,;6.01,2.63,;30.03,-.45,;30.03,-1.99,;31.36,.32,;32.7,-.45,;34.04,.32,;34.04,1.86,;32.71,2.63,;32.7,4.17,;34.03,4.94,;34.03,6.48,;35.37,4.17,;35.38,2.63,;32.7,-1.99,;31.36,-2.76,;34.04,-2.76,;35.6,-2.24,;36.63,-3.56,;35.68,-4.95,;34.28,-4.28,;32.97,-5.08,;31.62,-4.34,;33.02,-6.62,;31.71,-7.42,;30.35,-6.69,;29.04,-7.5,;31.74,-8.96,;33.1,-9.7,;30.43,-9.77,;30.48,-11.31,;31.83,-12.04,;31.88,-13.58,;30.57,-14.39,;33.23,-14.32,;29.17,-12.12,;27.81,-11.39,;29.21,-13.66,;27.89,-14.46,;27.93,-16,;26.62,-16.81,;29.29,-16.73,)|
Structure:
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