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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270790
Substrate
n/a
Meas. Tech.
ChEMBL_552585 (CHEMBL956457)
pH
6±n/a
Kd
4200±n/a nM
Comments
extracted
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270790
Synonyms:
CHEMBL451944 | QRFCTGHFGGLYPC
Type:
Small organic molecule
Emp. Form.:
C71H100N20O18S2
Mol. Mass.:
1585.807
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(O)=O |r,wU:86.88,101.106,80.84,73.76,27.35,51.61,4.4,41.43,wD:62.72,16.24,45.49,105.109,(33.08,-22.22,;33.08,-23.76,;34.43,-24.53,;31.74,-24.53,;31.74,-26.06,;30.41,-26.82,;29.08,-26.04,;29.08,-24.52,;27.76,-26.81,;26.42,-26.05,;25.08,-26.83,;25.08,-28.38,;23.73,-26.05,;22.4,-26.82,;21.07,-26.05,;21.07,-24.52,;19.75,-26.82,;19.75,-28.37,;21.07,-29.13,;22.4,-28.38,;23.73,-29.16,;23.73,-30.7,;22.39,-31.46,;21.05,-30.68,;18.41,-26.05,;17.08,-26.83,;17.08,-28.39,;15.74,-26.05,;15.74,-24.53,;17.08,-23.75,;18.49,-24.4,;19.53,-23.26,;18.77,-21.92,;17.26,-22.22,;14.41,-26.82,;13.07,-26.07,;13.07,-24.53,;11.74,-26.82,;10.42,-26.04,;9.09,-26.82,;9.09,-28.37,;7.75,-26.05,;6.41,-26.82,;5.08,-26.04,;5.08,-24.52,;3.76,-26.81,;3.76,-28.36,;5.08,-29.12,;2.42,-26.04,;1.1,-26.82,;1.1,-28.38,;-.25,-26.05,;-.25,-24.53,;1.1,-23.74,;2.44,-24.53,;3.78,-23.77,;3.78,-22.23,;2.45,-21.45,;1.11,-22.22,;-1.6,-26.79,;-2.95,-26.05,;-2.95,-24.52,;-4.28,-26.81,;-4.28,-28.36,;-2.95,-29.13,;-2.95,-30.68,;-1.6,-31.41,;-1.6,-32.95,;-2.96,-33.73,;-.27,-33.67,;-5.59,-26,;-6.9,-26.8,;-6.9,-28.33,;-8.24,-26.02,;-9.55,-26.74,;-8.24,-24.48,;-6.89,-23.7,;-6.89,-22.17,;-8.21,-21.41,;-5.55,-21.4,;7.75,-24.51,;6.42,-23.75,;9.09,-23.73,;33.08,-26.84,;33.08,-28.38,;34.41,-26.07,;35.75,-26.84,;37.07,-26.08,;37.07,-24.56,;35.76,-23.78,;35.77,-22.24,;37.1,-21.48,;37.09,-19.95,;38.43,-22.25,;38.43,-23.79,;35.75,-28.4,;34.41,-29.18,;37.07,-29.16,;38.65,-28.62,;39.68,-29.95,;38.73,-31.33,;37.33,-30.66,;36.1,-31.59,;34.71,-30.91,;36.21,-33.12,;34.93,-33.99,;33.55,-33.31,;32.27,-34.18,;35.04,-35.52,;33.76,-36.39,;36.43,-36.2,)|
Structure:
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