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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270837
Substrate
n/a
Meas. Tech.
ChEMBL_552584 (CHEMBL956456)
IC50
>125000±n/a nM
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270837
Synonyms:
(2S)-1-{2-[(2S)-2-[(2R)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-[(2S)-2-{3-[(2S,3R)-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-4-carbamoylbutanamido]-5-carbamimidamidopentanamido]-3-phenylpropanamido]-3-sulfanylpropanamido]-3-hydroxybutanamido]propanamido}-3-(1H-imidazol-5-yl)propanamido]-3-phenylpropanamido]acetamido}acetamido)-4-methylpentanamido]-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]formamido}-3-sulfanylpropanamido]-3-carbamoylpropanamido]acetyl}pyrrolidine-2-carboxylic acid | CHEMBL508702
Type:
Small organic molecule
Emp. Form.:
C83H118N24O22S2
Mol. Mass.:
1868.103
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O |r,wU:102.107,127.133,52.62,4.4,87.89,42.44,112.116,81.85,27.35,74.77,wD:63.73,16.24,46.50,106.110,(27.57,-7.77,;27.55,-9.3,;28.87,-10.1,;26.21,-10.06,;26.19,-11.6,;24.84,-12.33,;23.51,-11.56,;23.53,-10.02,;22.16,-12.31,;20.85,-11.51,;19.51,-12.27,;19.48,-13.81,;18.19,-11.48,;16.83,-12.21,;15.5,-11.44,;15.52,-9.9,;14.15,-12.19,;14.13,-13.72,;15.45,-14.52,;16.79,-13.78,;18.1,-14.57,;18.08,-16.12,;16.73,-16.86,;15.43,-16.07,;12.84,-11.38,;11.51,-12.15,;11.49,-13.69,;10.19,-11.36,;10.21,-9.82,;11.55,-9.07,;12.96,-9.73,;14,-8.59,;13.24,-7.25,;11.73,-7.54,;8.84,-12.11,;7.52,-11.32,;7.54,-9.78,;6.17,-12.07,;4.86,-11.28,;3.51,-12.03,;2.19,-11.24,;.84,-11.99,;2.21,-9.7,;.89,-8.9,;.89,-7.36,;2.24,-6.61,;-.42,-6.56,;-1.77,-7.31,;-1.8,-8.86,;-.4,-5.02,;-1.72,-4.23,;-3.07,-4.98,;-1.7,-2.69,;-.35,-1.94,;.97,-2.74,;.95,-4.29,;2.26,-5.07,;3.6,-4.32,;3.62,-2.77,;2.29,-1.99,;-3.02,-1.89,;-3.02,-.35,;-1.67,.4,;-4.34,.44,;-5.69,-.31,;-5.71,-1.85,;-7.05,-2.6,;-7.06,-4.14,;-8.41,-4.88,;-9.72,-4.09,;-8.43,-6.42,;-4.3,1.98,;-5.62,2.77,;-6.97,2.01,;-5.6,4.3,;-6.91,5.09,;-4.25,5.05,;-2.94,4.26,;-1.59,5.02,;-1.55,6.55,;-.27,4.22,;3.56,-8.94,;3.58,-7.41,;4.88,-9.74,;27.5,-12.39,;27.49,-13.92,;28.84,-11.63,;30.16,-12.44,;31.51,-11.69,;31.52,-10.15,;30.22,-9.37,;30.23,-7.83,;31.57,-7.07,;31.61,-5.52,;32.9,-7.85,;32.88,-9.39,;30.14,-13.97,;28.79,-14.72,;31.45,-14.77,;33.02,-14.28,;34.02,-15.62,;33.06,-17,;31.67,-16.3,;30.35,-17.1,;29,-16.36,;30.39,-18.64,;29.08,-19.44,;27.73,-18.7,;26.41,-19.49,;29.11,-20.97,;30.46,-21.71,;27.8,-21.77,;27.82,-23.31,;29.17,-24.05,;29.21,-25.59,;27.89,-26.38,;30.55,-26.34,;26.51,-24.11,;25.16,-23.37,;26.54,-25.65,;25.23,-26.45,;25.26,-27.99,;26.62,-28.73,;23.94,-28.79,;23.69,-30.44,;22.03,-30.71,;21.26,-29.23,;22.53,-28.31,;22.3,-26.79,;20.86,-26.24,;23.5,-25.83,)|
Structure:
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