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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270987
Substrate
n/a
Meas. Tech.
ChEMBL_552584 (CHEMBL956456)
IC50
570±n/a nM
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270987
Synonyms:
CHEMBL443697 | SYN-1327
Type:
Small organic molecule
Emp. Form.:
C70H100N18O16S2
Mol. Mass.:
1513.784
SMILES:
CC(C)C[C@H](N(C)C(=O)CN(C)C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(O)=O |r,wU:81.83,96.101,29.37,51.61,4.4,43.45,75.79,wD:62.65,18.26,47.49,100.104,(28.79,-21.8,;28.79,-23.34,;30.13,-24.11,;27.46,-24.11,;27.46,-25.65,;26.12,-26.42,;26.13,-27.96,;24.79,-25.65,;24.79,-24.1,;23.46,-26.42,;22.13,-25.65,;22.13,-24.11,;20.8,-26.43,;20.8,-27.96,;19.46,-25.66,;18.13,-26.42,;16.79,-25.66,;16.79,-24.11,;15.46,-26.43,;15.46,-27.97,;16.79,-28.74,;18.12,-27.97,;19.45,-28.74,;19.46,-30.27,;18.13,-31.05,;16.79,-30.29,;14.13,-25.66,;12.8,-26.44,;12.8,-27.98,;11.47,-25.67,;11.47,-24.12,;12.8,-23.36,;14.21,-23.99,;15.24,-22.84,;14.46,-21.51,;12.96,-21.83,;10.12,-26.42,;8.78,-25.66,;8.78,-24.11,;7.45,-26.43,;6.11,-25.65,;4.78,-26.43,;4.78,-27.96,;3.44,-25.65,;2.11,-26.42,;.78,-25.65,;.78,-24.11,;-.55,-26.43,;-1.88,-25.66,;-3.21,-26.44,;-3.21,-27.98,;-4.55,-25.67,;-4.55,-24.12,;-3.21,-23.36,;-1.87,-24.13,;-.54,-23.36,;-.54,-21.81,;-1.89,-21.05,;-3.21,-21.83,;-5.89,-26.43,;-7.22,-25.66,;-7.22,-24.12,;-8.55,-26.43,;-9.88,-25.65,;-8.55,-27.97,;-7.22,-28.74,;-7.22,-30.28,;-5.89,-31.04,;-5.87,-32.58,;-7.22,-33.35,;-4.55,-33.35,;-.55,-27.96,;.99,-27.97,;-2.1,-27.95,;-.55,-29.51,;3.44,-24.11,;2.12,-23.34,;4.78,-23.34,;28.79,-26.42,;28.79,-27.96,;30.13,-25.65,;31.45,-26.42,;32.79,-25.65,;32.79,-24.11,;31.47,-23.35,;31.46,-21.81,;32.79,-21.03,;32.79,-19.49,;34.13,-21.8,;34.14,-23.33,;31.45,-27.96,;30.13,-28.73,;32.79,-28.73,;34.36,-28.21,;35.39,-29.54,;34.44,-30.92,;33.04,-30.24,;31.81,-31.16,;30.39,-30.56,;31.79,-32.7,;30.45,-33.47,;29.13,-32.69,;27.78,-33.45,;30.44,-35.01,;29.1,-35.76,;31.76,-35.8,)|
Structure:
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