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Target
Cyclin-dependent kinase 2-associated protein 1
Ligand
BDBM50243666
Substrate
n/a
Meas. Tech.
ChEMBL_491562 (CHEMBL944208)
IC50
27000±n/a nM
Citation
 Janetka, JW; Almeida, L; Ashwell, S; Brassil, PJ; Daly, K; Deng, C; Gero, T; Glynn, RE; Horn, CL; Ioannidis, S; Lyne, P; Newcombe, NJ; Oza, VB; Pass, M; Springer, SK; Su, M; Toader, D; Vasbinder, MM; Yu, D; Yu, Y; Zabludoff, SD Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors. Bioorg Med Chem Lett 18:4242-8 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2-associated protein 1
Synonyms:
CDK2AP1 | CDKA1_HUMAN | CDKAP1 | DOC1
Type:
PROTEIN
Mol. Mass.:
12370.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_491562
Residue:
115
Sequence:
MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS
  
Inhibitor
Name:
BDBM50243666
Synonyms:
(+/-)-1-(5-(3-(2-(diethylamino)ethoxy)phenyl)-3-(piperidin-3-ylcarbamoyl)thiophen-2-yl)urea | CHEMBL471549
Type:
Small organic molecule
Emp. Form.:
C23H33N5O3S
Mol. Mass.:
459.605
SMILES:
CCN(CC)CCOc1cccc(c1)-c1cc(C(=O)NC2CCCNC2)c(NC(N)=O)s1
Structure:
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