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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50010874
Substrate
n/a
Meas. Tech.
ChEMBL_487422 (CHEMBL1020016)
IC50
120±n/a nM
Citation
 Mahaney, PE; Gavrin, LK; Trybulski, EJ; Stack, GP; Vu, TA; Cohn, ST; Ye, F; Belardi, JK; Santilli, AA; Sabatucci, JP; Leiter, J; Johnston, GH; Bray, JA; Burroughs, KD; Cosmi, SA; Leventhal, L; Koury, EJ; Zhang, Y; Mugford, CA; Ho, DM; Rosenzweig-Lipson, SJ; Platt, B; Smith, VA; Deecher, DC Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. J Med Chem 51:4038-49 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50010874
Synonyms:
1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclohexanol | 1-[1-(4-Chloro-phenyl)-2-dimethylamino-ethyl]-cyclohexanol (HCl) | CHEMBL420644
Type:
Small organic molecule
Emp. Form.:
C16H24ClNO
Mol. Mass.:
281.821
SMILES:
CN(C)CC(c1ccc(Cl)cc1)C1(O)CCCCC1
Structure:
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