Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50252093
Substrate
n/a
Meas. Tech.
ChEMBL_487696 (CHEMBL1010313)
IC50
1770±n/a nM
Citation
 Innocenti, A; Maresca, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors? Bioorg Med Chem Lett 18:3938-41 (2008) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50252093
Synonyms:
6-hydroxybenzo[d][1,3]oxathiol-2-one | CHEMBL442687 | cid_72139
Type:
Small organic molecule
Emp. Form.:
C7H4O3S
Mol. Mass.:
168.17
SMILES:
Oc1ccc2sc(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: