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Target
Egl nine homolog 1
Ligand
BDBM50251901
Substrate
n/a
Meas. Tech.
ChEMBL_488018 (CHEMBL983035)
IC50
>40000±n/a nM
Citation
 Tegley, CM; Viswanadhan, VN; Biswas, K; Frohn, MJ; Peterkin, TA; Chang, C; Bürli, RW; Dao, JH; Veith, H; Rogers, N; Yoder, SC; Biddlecome, G; Tagari, P; Allen, JR; Hungate, RW Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation. Bioorg Med Chem Lett 18:3925-8 (2008) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50251901
Synonyms:
CHEMBL479404 | ethyl 2-(2-(2-(phenylsulfonyl)acetamido)thiazol-4-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C15H16N2O5S2
Mol. Mass.:
368.428
SMILES:
CCOC(=O)Cc1csc(NC(=O)CS(=O)(=O)c2ccccc2)n1
Structure:
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