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Target
Bcl-2-like protein 2
Ligand
BDBM50251616
Substrate
n/a
Meas. Tech.
ChEMBL_488051 (CHEMBL983861)
Ki
12950±n/a nM
Citation
 Dömling, A; Antuch, W; Beck, B; Schauer-Vukasinovic, V Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-XL protein interaction antagonist. Bioorg Med Chem Lett 18:4115-7 (2008) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM50251616
Synonyms:
CHEMBL521427 | biphenyl-4-carboxylic acid methyl-[(3-nitro-4-thiomorpholin-4-yl-phenyl-carbamoyl)-methyl]-amide
Type:
Small organic molecule
Emp. Form.:
C26H26N4O4S
Mol. Mass.:
490.574
SMILES:
CN(CC(=O)Nc1ccc(N2CCSCC2)c(c1)[N+]([O-])=O)C(=O)c1ccc(cc1)-c1ccccc1
Structure:
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