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Target
Heat shock protein beta-1
Ligand
BDBM50263093
Substrate
n/a
Meas. Tech.
ChEMBL_489080 (CHEMBL987300)
IC50
53±n/a nM
Citation
 Angell, RM; Angell, TD; Bamborough, P; Bamford, MJ; Chung, CW; Cockerill, SG; Flack, SS; Jones, KL; Laine, DI; Longstaff, T; Ludbrook, S; Pearson, R; Smith, KJ; Smee, PA; Somers, DO; Walker, AL Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg Med Chem Lett 18:4433-7 (2008) [PubMed]  Article 
Target
Name:
Heat shock protein beta-1
Synonyms:
HSP27 | HSP28 | HSPB1 | HSPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
22781.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1500622
Residue:
205
Sequence:
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK
  
Inhibitor
Name:
BDBM50263093
Synonyms:
6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopropylamide 4'-cyclopropylmethyl-amide | CHEMBL478649 | N3-cyclopropyl-N4'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide | N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide
Type:
Small organic molecule
Emp. Form.:
C22H24N2O2
Mol. Mass.:
348.4382
SMILES:
Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1
Structure:
Search PDB for entries with ligand similarity: