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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50245193
Substrate
n/a
Meas. Tech.
ChEMBL_489766 (CHEMBL989249)
EC50
2.1±n/a nM
Citation
 Zhu, C; Hansen, AR; Bateman, T; Chen, Z; Holt, TG; Hubert, JA; Karanam, BV; Lee, SJ; Pan, J; Qian, S; Reddy, VB; Reitman, ML; Strack, AM; Tong, V; Weingarth, DT; Wolff, MS; MacNeil, DJ; Weber, AE; Duffy, JL; Edmondson, SD Discovery of imidazole carboxamides as potent and selective CCK1R agonists. Bioorg Med Chem Lett 18:4393-6 (2008) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49196.59
Organism:
MOUSE
Description:
Cholecystokinin A CCKBR MOUSE::P56481
Residue:
453
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50245193
Synonyms:
(1-(3-ethoxyphenyl)-2-p-tolyl-1H-imidazol-4-yl)(4-(quinolin-3-yl)piperazin-1-yl)methanone | CHEMBL453083 | CHEMBL503822
Type:
Small organic molecule
Emp. Form.:
C32H31N5O2
Mol. Mass.:
517.6208
SMILES:
CCOc1cccc(c1)-n1cc(nc1-c1ccc(C)cc1)C(=O)N1CCN(CC1)c1cnc2ccccc2c1
Structure:
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