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Target
Coagulation factor X
Ligand
BDBM50262350
Substrate
n/a
Meas. Tech.
ChEMBL_509609 (CHEMBL1001370)
IC50
506±n/a nM
Citation
 O'Connor, SP; Atwal, K; Li, C; Liu, EC; Seiler, SM; Shi, M; Shi, Y; Stein, PD; Wang, Y Synthesis and evaluation of acylguanidine FXa inhibitors. Bioorg Med Chem Lett 18:4696-9 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50262350
Synonyms:
(S)-1-benzoyl-N-((4-methoxyphenylamino)(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-ylamino)methylene)piperidine-4-carboxamide | CHEMBL443648
Type:
Small organic molecule
Emp. Form.:
C33H42N6O5
Mol. Mass.:
602.7238
SMILES:
COc1ccc(NC(NC(=O)C2CCN(CC2)C(=O)c2ccccc2)=N[C@H]2CCCCN(CC(=O)N3CCCC3)C2=O)cc1 |r,w:7.6|
Structure:
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