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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50131739
Substrate
n/a
Meas. Tech.
ChEMBL_514885 (CHEMBL972693)
EC50
130±n/a nM
Citation
 Kasuga, J; Oyama, T; Hirakawa, Y; Makishima, M; Morikawa, K; Hashimoto, Y; Miyachi, H Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part. Bioorg Med Chem Lett 18:4525-8 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50131739
Synonyms:
(+/-)-2-(4-methoxy-3-((4-(trifluoromethyl)benzamido)methyl)benzyl)butanoic acid | 2-(4-methoxy-3-((4-(trifluoromethyl)benzamido)methyl)benzyl)butanoic acid | 2-{4-Methoxy-3-[(4-trifluoromethyl-benzoylamino)-methyl]-benzyl}-butyric acid | 2-{4-methoxy-3-[(4-trifluoromethylbenzoylamino)-methyl]phenylmethyl}butyric acid | CHEMBL118939
Type:
Small organic molecule
Emp. Form.:
C21H22F3NO4
Mol. Mass.:
409.3989
SMILES:
CCC(Cc1ccc(OC)c(CNC(=O)c2ccc(cc2)C(F)(F)F)c1)C(O)=O
Structure:
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