Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50272829
Substrate
n/a
Meas. Tech.
ChEMBL_509965 (CHEMBL1005558)
IC50
14.2±n/a nM
Citation
 Chimenti, FMaccioni, ESecci, DBolasco, AChimenti, PGranese, ACarradori, SAlcaro, SOrtuso, FYáñez, MOrallo, FCirilli, RFerretti, RLa Torre, F Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones. J Med Chem 51:4874-80 (2008) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50272829
Synonyms:
(+/-)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine | CHEMBL1240558 | CHEMBL498505
Type:
Small organic molecule
Emp. Form.:
C16H17F2N3S
Mol. Mass.:
321.388
SMILES:
CC1CCCCC1=NNc1nc(cs1)-c1ccc(F)cc1F |w:7.8|
Structure:
Search PDB for entries with ligand similarity: