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Target
Delta-type opioid receptor
Ligand
BDBM50240437
Substrate
n/a
Meas. Tech.
ChEMBL_510226 (CHEMBL1005604)
Ki
12±n/a nM
Citation
 Fulton, BS; Knapp, BI; Bidlack, JM; Neumeyer, JL Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors. Bioorg Med Chem Lett 18:4474-6 (2008) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50240437
Synonyms:
(-)-17-(cyclobutylmethyl)morphinan-3,14-diol | (-)-N-cyclobutylmethyl-3,14-dihydroxymorphinan | (-)-butorphanol | 17-(cyclobutylmethyl)morphinan-3,14-diol | BUTORPHANOL | CHEMBL33986 | US10231963, Table B.3 | US10736890, Compound TABLE B.3 | US11534436, Compound Table B.3 | US9656961, Example 00120
Type:
Small organic molecule
Emp. Form.:
C21H29NO2
Mol. Mass.:
327.4605
SMILES:
Oc1ccc2C[C@H]3N(CC4CCC4)CC[C@@]4(CCCC[C@@]34O)c2c1 |r,TLB:8:7:4.22.5:20|
Structure:
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