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Target
Bile salt-activated lipase
Ligand
BDBM50244756
Substrate
n/a
Meas. Tech.
ChEMBL_512655 (CHEMBL969705)
IC50
11000±n/a nM
Citation
 Eilfeld, A; González Tanarro, CM; Frizler, M; Sieler, J; Schulze, B; Gütschow, M Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides. Bioorg Med Chem 16:8127-35 (2008) [PubMed]  Article 
Target
Name:
Bile salt-activated lipase
Synonyms:
BAL | CEL | CEL_HUMAN | Cholesterol esterase
Type:
PROTEIN
Mol. Mass.:
79308.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_512655
Residue:
753
Sequence:
MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF
  
Inhibitor
Name:
BDBM50244756
Synonyms:
2-(2,3,5,6-Tetrafluoropyridin-4-yl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | CHEMBL518500
Type:
Small organic molecule
Emp. Form.:
C12H4F4N2O3S
Mol. Mass.:
332.23
SMILES:
Fc1nc(F)c(F)c(N2C(=O)c3ccccc3S2(=O)=O)c1F
Structure:
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