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Target
B1 bradykinin receptor
Ligand
BDBM50244619
Substrate
n/a
Meas. Tech.
ChEMBL_512960 (CHEMBL977296)
IC50
85.9±n/a nM
Citation
 Biswas, K; Aya, T; Qian, W; Peterkin, TA; Chen, JJ; Human, J; Hungate, RW; Kumar, G; Arik, L; Lester-Zeiner, D; Biddlecome, G; Manning, BH; Sun, H; Dong, H; Huang, M; Loeloff, R; Johnson, EJ; Askew, BC Aryl sulfones as novel bradykinin B1 receptor antagonists for treatment of chronic pain. Bioorg Med Chem Lett 18:4764-9 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
BDKRB1 | BKRB1_RABIT | Bradykinin B1 receptor
Type:
PROTEIN
Mol. Mass.:
39519.62
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_796432
Residue:
352
Sequence:
MASQGPLELQPSNQSQLAPPNATSCSGAPDAWDLLHRLLPTFIIAIFTLGLLGNSFVLSVFLLARRRLSVAEIYLANLAASDLVFVLGLPFWAENVRNQFDWPFGAALCRIVNGVIKANLFISIFLVVAISQDRYSVLVHPMASRRGRRRRQAQATCALIWLAGGLLSTPTFVLRSVRAVPELNVSACILLLPHEAWHWLRMVELNLLGFLLPLAAILFFNCHILASLRRRGERVPSRCGGPRDSKSTALILTLVASFLVCWAPYHFFAFLECLWQVHAIGGCFWEEFTDLGLQLSNFSAFVNSCLNPVIYVFVGRLFRTKVWELCQQCSPRSLAPVSSSRRKEMLWGFWRN
  
Inhibitor
Name:
BDBM50244619
Synonyms:
(2R,3S)-4-(3-chlorophenylsulfonyl)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)butanamide | CHEMBL508632
Type:
Small organic molecule
Emp. Form.:
C26H33ClN2O5S
Mol. Mass.:
521.069
SMILES:
O[C@H](CS(=O)(=O)c1cccc(Cl)c1)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12 |r|
Structure:
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