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Target
M-phase inducer phosphatase 2
Ligand
BDBM50118676
Substrate
n/a
Meas. Tech.
ChEMBL_510972 (CHEMBL1003159)
IC50
23630±n/a nM
Citation
 Park, H; Bahn, YJ; Jung, SK; Jeong, DG; Lee, SH; Seo, I; Yoon, TS; Kim, SJ; Ryu, SE Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening. J Med Chem 51:5533-41 (2008) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50118676
Synonyms:
2-(2-Hydroxy-ethylsulfanyl)-3-methyl-[1,4]naphthoquinone | 2-(2-hydroxyethylthio)-3-methylnaphthalene-1,4-dione | CHEMBL92659
Type:
Small organic molecule
Emp. Form.:
C13H12O3S
Mol. Mass.:
248.298
SMILES:
CC1=C(SCCO)C(=O)c2ccccc2C1=O |c:1|
Structure:
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