Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 1
Ligand
BDBM50253593
Substrate
n/a
Meas. Tech.
ChEMBL_510974 (CHEMBL1003161)
Ki
21370±n/a nM
Citation
 Park, H; Bahn, YJ; Jung, SK; Jeong, DG; Lee, SH; Seo, I; Yoon, TS; Kim, SJ; Ryu, SE Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening. J Med Chem 51:5533-41 (2008) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50253593
Synonyms:
2-(3,4-Dimethylphenylamino)-5-(3-furan-2-ylallylidene)thiazol-4-one | 2-(3,4-dimethylphenylamino)-5-(3-(furan-2-yl)allylidene)thiazol-4(5H)-one | CHEMBL523844 | cid_5588055
Type:
Small organic molecule
Emp. Form.:
C18H16N2O2S
Mol. Mass.:
324.397
SMILES:
Cc1ccc(NC2=NC(=O)C(S2)=CC=Cc2ccco2)cc1C |w:12.13,14.15,t:6|
Structure:
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