Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50264231
Substrate
n/a
Meas. Tech.
ChEMBL_535370 (CHEMBL983496)
IC50
87±n/a nM
Citation
 Deng, Q; Frie, JL; Marley, DM; Beresis, RT; Ren, N; Cai, TQ; Taggart, AK; Cheng, K; Carballo-Jane, E; Wang, J; Tong, X; Waters, MG; Tata, JR; Colletti, SL Molecular modeling aided design of nicotinic acid receptor GPR109A agonists. Bioorg Med Chem Lett 18:4963-7 (2008) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50264231
Synonyms:
2-(3-(6-methoxynaphthalen-2-yl)propanamido)benzoic acid | CHEMBL492220
Type:
Small organic molecule
Emp. Form.:
C21H19NO4
Mol. Mass.:
349.3799
SMILES:
COc1ccc2cc(CCC(=O)Nc3ccccc3C(O)=O)ccc2c1
Structure:
Search PDB for entries with ligand similarity: