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Target
Protein kinase domain-containing protein
Ligand
BDBM50265102
Substrate
n/a
Meas. Tech.
ChEMBL_496798 (CHEMBL1008811)
IC50
8000±n/a nM
Citation
 Bouloc, N; Large, JM; Smiljanic, E; Whalley, D; Ansell, KH; Edlin, CD; Bryans, JS Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Bioorg Med Chem Lett 18:5294-8 (2008) [PubMed]  Article 
Target
Name:
Protein kinase domain-containing protein
Synonyms:
Putative uncharacterized protein pk7
Type:
PROTEIN
Mol. Mass.:
37967.83
Organism:
Plasmodium falciparum
Description:
ChEMBL_496798
Residue:
320
Sequence:
MKDILSNYSNLIYLNKYVKEKDKYINDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALVTAK
  
Inhibitor
Name:
BDBM50265102
Synonyms:
4-(6-(4-morpholinobenzylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile | CHEMBL497559
Type:
Small organic molecule
Emp. Form.:
C24H22N6O
Mol. Mass.:
410.4711
SMILES:
N#Cc1ccc(cc1)-c1cnc2ccc(NCc3ccc(cc3)N3CCOCC3)nn12
Structure:
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