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Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50266130
Substrate
n/a
Meas. Tech.
ChEMBL_543909 (CHEMBL1019505)
IC50
25±n/a nM
Citation
 Blagg, J; Mowbray, C; Pryde, D; Salmon, G; Fairman, D; Schmid, E; Beaumont, K Small, non-peptide C5a receptor antagonists: part 2. Bioorg Med Chem Lett 18:5605-8 (2008) [PubMed]  Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50266130
Synonyms:
(+/-)-N-(1-(4-chlorophenyl)-3-(dimethylamino)propan-2-yl)-2-ethyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)benzamide | CHEMBL467571
Type:
Small organic molecule
Emp. Form.:
C28H37ClN2O3
Mol. Mass.:
485.058
SMILES:
CCc1ccccc1C(=O)N(C(CN(C)C)Cc1ccc(Cl)cc1)C1CCC2(CC1)OCCO2
Structure:
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