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Target
Cyclin-dependent kinase 4
Ligand
BDBM50274807
Substrate
n/a
Meas. Tech.
ChEMBL_536408 (CHEMBL992479)
IC50
140±n/a nM
Citation
 Anderson, M; Andrews, DM; Barker, AJ; Brassington, CA; Breed, J; Byth, KF; Culshaw, JD; Finlay, MR; Fisher, E; McMiken, HH; Green, CP; Heaton, DW; Nash, IA; Newcombe, NJ; Oakes, SE; Pauptit, RA; Roberts, A; Stanway, JJ; Thomas, AP; Tucker, JA; Walker, M; Weir, HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:5487-92 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50274807
Synonyms:
CHEMBL457887 | N-(4-(3-(dimethylamino)propylsulfonyl)phenyl)-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-amine
Type:
Small organic molecule
Emp. Form.:
C22H30N6O2S
Mol. Mass.:
442.578
SMILES:
CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)CCCN(C)C)n1
Structure:
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