Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50252724
Substrate
n/a
Meas. Tech.
ChEMBL_539504 (CHEMBL1032313)
Ki
2.4±n/a nM
Citation
 Oberdorf, C; Schepmann, D; Vela, JM; Diaz, JL; Holenz, J; Wünsch, B Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans]. J Med Chem 51:6531-7 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50252724
Synonyms:
3-Methoxy-1-(3-phenylpropyl)-6,7-dihydrospiro[piperidine-4,4-thieno[3.2-c]pyran] | CHEMBL495311
Type:
Small organic molecule
Emp. Form.:
C21H27NO2S
Mol. Mass.:
357.51
SMILES:
COC1Cc2sccc2C2(CCN(CCCc3ccccc3)CC2)O1
Structure:
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